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Mitoxantrone dihydrochloride_Molecular_structure_CAS_70476-82-3)
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Mitoxantrone dihydrochloride

Catalog No. M6545 Name Sigma Aldrich
CAS Number 70476-82-3 Website http://www.sigmaaldrich.com
M. F. C22H30Cl2N4O6 Telephone 1-800-521-8956
M. W. 517.4028 Fax
Purity ≥97% (HPLC) Email
Storage Chembase ID: 72816


IUPAC name
1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
IUPAC Traditional name
mitoxantrone dihydrochloride
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride


PubChem SID 24278562
CAS Number 70476-82-3
MDL Number MFCD00242943
EC Number 274-619-1


Purity ≥97% (HPLC)
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H360
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 46-61
RTECS CB5748500
Safety Statements 53-36/37/39-45
German water hazard class 3


Description (English)
Biochem/physiol Actions
Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.