Mitoxantrone dihydrochloride

• Catalog No.: M6545
• CAS Number: 70476-82-3
• M. F.: C22H30Cl2N4O6
• M. W.: 517.4028
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
• IUPAC Traditional name: mitoxantrone dihydrochloride
• Synonyms: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

DATABASE IDS

• PubChem SID: 24278562
• CAS Number: 70476-82-3
• MDL Number: MFCD00242943
• EC Number: 274-619-1

PROPERTIES

• Purity: ≥97% (HPLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 46-61
• RTECS: CB5748500
• Safety Statements: 53-36/37/39-45
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.