Home > Compound List > Product Information
Phytosphingosine hydrochloride_Molecular_structure_CAS_554-62-1)
Click picture or here to close

Phytosphingosine hydrochloride

Catalog No. P2795 Name Sigma Aldrich
CAS Number 554-62-1 Website http://www.sigmaaldrich.com
M. F. C18H40ClNO3 Telephone 1-800-521-8956
M. W. 353.9681 Fax
Purity ~97% Email
Storage Chembase ID: 133606

SYNONYMS

IUPAC name
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol hydrochloride
IUPAC Traditional name
phytosphingosine hydrochloride
Synonyms
PHS
D-Ribo-2-aminooctadecane-1,3,4-triol
4-Hydroxysphinganine
D-Ribo-1,3,4-trihydroxy-2-aminooctadecane

DATABASE IDS

CAS Number 554-62-1
PubChem SID 24898363
MDL Number MFCD06804643

PROPERTIES

Biological Source from Saccharomyces cerevisiae
Purity ~97%
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 1

DETAILS

Description (English)
Biochem/physiol Actions
Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

REFERENCES