Guanosine 3′,5′-cyclic monophosphate

• Catalog No.: G7504
• CAS Number: 7665-99-8
• M. F.: C10H12N5O7P
• M. W.: 345.205341
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-amino-9-{2,7-dihydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-6-yl}-6,9-dihydro-3H-purin-6-one
• IUPAC Traditional name: cyclic guanosine monophosphate
• Synonyms: cGMP; cyclic GMP

DATABASE IDS

• MDL Number: MFCD00070129
• EC Number: 231-641-6
• PubChem SID: 24895309
• CAS Number: 7665-99-8

PROPERTIES

• Purity: ≥98% (HPLC)
• Apperance: white powder
• Solubility: 1% NaHCO3: soluble50 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 22-26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. G7504.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.