2-(Methylthio)adenosine 5′-diphosphate trisodium salt hydrate

• Catalog No.: M152
• CAS Number: 475193-31-8(anhydrous)
• M. F.: C11H16N5Na3O11P2S
• M. W.: 557.253472
• Purity: ≥89% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: trisodium hydrate [(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl (phosphonatooxy)phosphonate
• IUPAC Traditional name: trisodium hydrate [(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl phosphonatooxyphosphonate
• Synonyms: 2-Methylthio-ADP trisodium salt hydrate; 2-(Methylthio)adenosine 5′-trihydrogen diphosphate trisodium salt hydrate

DATABASE IDS

• CAS Number: 475193-31-8(anhydrous)
• PubChem SID: 24278816
• MDL Number: MFCD11044463

PROPERTIES

• Apperance: white solid
• Solubility: H2O: >20 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Condition: desiccated
• Storage Temperature: -20°C
• German water hazard class: 3
• Purity: ≥89% (HPLC)

DETAILS

Description (English)

Caution
Hygroscopic, air sensitive
Biochem/physiol Actions
2-Methylthio-ADP (2-ME-SADP) is a P2 purinoceptor agonist, which induces platelet aggregation and shape change and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1. Compared with ADP, 2-methylthio-ADP was 3-5 times as active as an aggregating agent and 150-200 times as active as an inhibitor of cyclic AMP accumulation. Purinergic signaling may be an important factor in TSP-1-mediated cell-matrix and cell-cell interactions such as those occurring during development and repair.