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2-(Methylthio)adenosine 5′-diphosphate trisodium salt hydrate_Molecular_structure_CAS_475193-31-8(anhydrous))
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2-(Methylthio)adenosine 5′-diphosphate trisodium salt hydrate

Catalog No. M152 Name Sigma Aldrich
CAS Number 475193-31-8(anhydrous) Website http://www.sigmaaldrich.com
M. F. C11H16N5Na3O11P2S Telephone 1-800-521-8956
M. W. 557.253472 Fax
Purity ≥89% (HPLC) Email
Storage desiccated Chembase ID: 133570


IUPAC name
trisodium hydrate [(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl (phosphonatooxy)phosphonate
IUPAC Traditional name
trisodium hydrate [(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl phosphonatooxyphosphonate
2-Methylthio-ADP trisodium salt hydrate
2-(Methylthio)adenosine 5′-trihydrogen diphosphate trisodium salt hydrate


CAS Number 475193-31-8(anhydrous)
PubChem SID 24278816
MDL Number MFCD11044463


Apperance white solid
Solubility H2O: >20 mg/mL
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Condition desiccated
Storage Temperature -20°C
German water hazard class 3
Purity ≥89% (HPLC)


Description (English)
Hygroscopic, air sensitive
Biochem/physiol Actions
2-Methylthio-ADP (2-ME-SADP) is a P2 purinoceptor agonist, which induces platelet aggregation and shape change and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1. Compared with ADP, 2-methylthio-ADP was 3-5 times as active as an aggregating agent and 150-200 times as active as an inhibitor of cyclic AMP accumulation. Purinergic signaling may be an important factor in TSP-1-mediated cell-matrix and cell-cell interactions such as those occurring during development and repair.