Geldanamycin from Streptomyces hygroscopicus

• Catalog No.: G3381
• CAS Number: 30562-34-6
• M. F.: C29H40N2O9
• M. W.: 560.6359
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (4Z,6Z,8S,9S,10Z,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• IUPAC Traditional name: (4Z,6Z,8S,9S,10Z,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

DATABASE IDS

• MDL Number: MFCD00274570
• CAS Number: 30562-34-6

PROPERTIES

• Purity: ≥98% (HPLC)
• Quality Level: PREMIUM
• Apperance: yellow to orange powder
• Solubility: DMSO: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: LX8920000
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.