Doxepin hydrochloride

• Catalog No.: D4526
• CAS Number: 1229-29-4
• M. F.: C19H22ClNO
• M. W.: 315.83708
• Purity: ≥98% (GC)

SYNONYMS

• Title: 多虑平 盐酸盐
• IUPAC name: dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ylidene]propyl})amine hydrochloride
• IUPAC Traditional name: dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ylidene]propyl})amine hydrochloride
• Synonyms: 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

DATABASE IDS

• CAS Number: 1229-29-4
• MDL Number: MFCD00079135
• EC Number: 214-966-8
• PubChem SID: 24278093

PROPERTIES

• Purity: ≥98% (GC)
• Purity: 15% Z-isomer basis
• Purity: ~85% E-isomer basis
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
• Apperance: white to off-white powder
• Solubility: 1 M HCl: soluble50 mg/mL
• Solubility: H2O: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• RTECS: HQ4375000
• Safety Statements: 36/37/39-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Mixture of cis- and trans-isomers
Biochem/physiol Actions
Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.