Ribostamycin sulfate salt

• Catalog No.: R2255
• CAS Number: 53797-35-6
• M. F.: C17H36N4O14S
• M. W.: 552.55114

SYNONYMS

• IUPAC name: (2S,3R,4S,5S,6S)-5-amino-2-(aminomethyl)-6-{[(1S,2S,3R,4S,6R)-4,6-diamino-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol; sulfuric acid
• IUPAC Traditional name: (2S,3R,4S,5S,6S)-5-amino-2-(aminomethyl)-6-{[(1S,2S,3R,4S,6R)-4,6-diamino-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol; sulfuric acid

DATABASE IDS

• CAS Number: 53797-35-6
• EC Number: 258-783-1
• MDL Number: MFCD00057496

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H312-H332-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P280-P308 + P313
• Risk Statements: 61-20/21/22
• RTECS: WK2300000
• Safety Statements: 53-22-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Ribostamycin is a broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. It is used in pharmacokinetic and nephrotoxicity studies1,2.
Biochem/physiol Actions
Aminoglycosides, such as ribostamycin, bind to the bacterial 30S and 50S ribosomal subunit, which inhibits the translocation of the peptidyl-tRNA from the A-site to the P-site. This causes misreading of mRNA which makes bacteria unable to make essential proteins3. It also inhibits the chaperone activity of protein disulfide isomerase (PDI).