(±)-Gossypol from cotton seeds

• Catalog No.: G8761
• CAS Number: 303-45-7
• M. F.: C30H30O8
• M. W.: 518.5544
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde
• IUPAC Traditional name: gossypol
• Synonyms: (±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)

DATABASE IDS

• PubChem SID: 24895349
• MDL Number: MFCD00017352
• CAS Number: 303-45-7

PROPERTIES

• Purity: ≥95% (HPLC)
• Gene Information: human ... AKR1B1(231), BAD(572), BCL2(596), LDHA(3939), LDHB(3945), MCL1(4170)
• GHS Signal Word: Warning
• GHS Hazard statements: H351
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P281
• Risk Statements: 22-40
• RTECS: DU3100000
• Safety Statements: 22-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Gossypol is a male antifertility agent and PAF antagonist/inhibitor. Gossypol is a poisonous pigment found in cottonseed and its name is derived from the botanical name of the cotton plant, Gossypium.. Gossypium is extracted from selected hybrid species between two Gossypium species, Gossypium hirsutum and Gossypium barbadens. As a PAF antagonist/inhibitor, Gossypium markedly inhibited the contractile responses of guinea pig lung parenchyma strips stimulated with leukotriene B4, seukotriene D4, and PAF-acether.