Bradykinin Fragment 1-5

• Catalog No.: B1401
• CAS Number: 23815-89-6
• M. F.: C27H40N8O6
• M. W.: 572.6565
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 2-[2-({1-[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidine-2-carbonyl]pyrrolidin-2-yl}formamido)acetamido]-3-phenylpropanoic acid
• IUPAC Traditional name: 2-[2-({1-[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidine-2-carbonyl]pyrrolidin-2-yl}formamido)acetamido]-3-phenylpropanoic acid

DATABASE IDS

• PubChem SID: 24891591
• MDL Number: MFCD00076260
• CAS Number: 23815-89-6

PROPERTIES

• Purity: ≥97% (HPLC)
• Gene Information: human ... KNG1 (includes EG:3827)(3827)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe
Biochem/physiol Actions
The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.