1α,25-Dihydroxyvitamin D3

• Catalog No.: D1530
• CAS Number: 32222-06-3
• M. F.: C27H44O3
• M. W.: 416.63646
• Purity: ≥99% (HPLC)

SYNONYMS

• IUPAC name: (1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• IUPAC Traditional name: calcitriol
• Synonyms: Calcitriol; 1α,25-Dihydroxycholecalciferol

DATABASE IDS

• MDL Number: MFCD00867079
• EC Number: 250-963-8
• PubChem SID: 24893473
• Beilstein Number: 7559394
• CAS Number: 32222-06-3

PROPERTIES

• Purity: ≥99% (HPLC)
• Quality Level: PREMIUM
• Gene Information: human ... VDR(7421)
• Solubility: Do you have solubility information on this product that you would like to share?
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330-H361
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 2811 6.1/PG 1
• Risk Statements: 63-26/27/28
• RTECS: FZ4645000
• Safety Statements: 36/37/39-45
• Storage Temperature: -20°C
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Frequently Asked Questions
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Application
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Biochem/physiol Actions
Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.