Semustine

• Catalog No.: S4026
• CAS Number: 13909-09-6
• M. F.: C10H18ClN3O2
• M. W.: 247.72182

SYNONYMS

• Title: 司莫司汀
• IUPAC name: 3-(2-chloroethyl)-1-(4-methylcyclohexyl)-3-nitrosourea
• IUPAC Traditional name: semustine
• Synonyms: N-(2-氯乙基)-N′-(4-甲基环己基)-N-亚硝脲; Methyl-CCNU

DATABASE IDS

• PubChem SID: 24899584
• MDL Number: MFCD00133811
• CAS Number: 13909-09-6

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H300-H311-H315-H319-H331-H335-H350-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P261-P264-P280-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 2
• Risk Statements: 45-46-23/24/25-36/37/38
• RTECS: YS5000000
• Safety Statements: 53-22-26-36/37/39-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Application
Commonly used in pharmacological studies involving:
• Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1
• CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2
• Investigations into its use for chemotherapy3,4