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Guanosine 5′-[γ-thio]triphosphate tetralithium salt_Molecular_structure_CAS_94825-44-2)
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Guanosine 5′-[γ-thio]triphosphate tetralithium salt

Catalog No. G8634 Name Sigma Aldrich
CAS Number 94825-44-2 Website http://www.sigmaaldrich.com
M. F. C10H12Li4N5O13P3S Telephone 1-800-521-8956
M. W. 562.978263 Fax
Purity ≥75% (HPLC) Email
Storage Chembase ID: 133362


IUPAC name
tetralithium(1+) ion [(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[dioxido(sulfanylidene)-λ5-phosphanyl phosphonato]oxy}phosphonate
IUPAC Traditional name
tetralithium(1+) ion [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [dioxido(sulfanylidene)-λ5-phosphanyl phosphonato]oxyphosphonate
GTPγS tetralithium salt
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt


EC Number 305-606-1
PubChem SID 24895344
CAS Number 94825-44-2
MDL Number MFCD00135151
Beilstein Number 8182249


Apperance off-white powder
Solubility H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 26-36
Storage Temperature -20°C
German water hazard class 3
Purity ≥75% (HPLC)
Shipped in dry ice


Description (English)
Biochem/physiol Actions
GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.