Guanosine 5′-[γ-thio]triphosphate tetralithium salt

• Catalog No.: G8634
• CAS Number: 94825-44-2
• M. F.: C10H12Li4N5O13P3S
• M. W.: 562.978263
• Purity: ≥75% (HPLC)

SYNONYMS

• IUPAC name: tetralithium(1+) ion [(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[dioxido(sulfanylidene)-λ^5-phosphanyl phosphonato]oxy}phosphonate
• IUPAC Traditional name: tetralithium(1+) ion [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [dioxido(sulfanylidene)-λ^5-phosphanyl phosphonato]oxyphosphonate
• Synonyms: GTP-γ-S-Li4; GTPγS tetralithium salt; Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

DATABASE IDS

• EC Number: 305-606-1
• PubChem SID: 24895344
• CAS Number: 94825-44-2
• MDL Number: MFCD00135151
• Beilstein Number: 8182249

PROPERTIES

• Apperance: off-white powder
• Solubility: H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3
• Purity: ≥75% (HPLC)
• Shipped in: dry ice

DETAILS

Description (English)

Biochem/physiol Actions
GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.