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Catalog No. S3132 Name Sigma Aldrich
CAS Number 3211-76-5 Website http://www.sigmaaldrich.com
M. F. C5H11NO2Se Telephone 1-800-521-8956
M. W. 196.10634 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 133348


IUPAC name
(2S)-2-amino-4-(methylselanyl)butanoic acid
IUPAC Traditional name
(S)-2-Amino-4-(methylseleno)butyric acid


CAS Number 3211-76-5
PubChem SID 24899544
MDL Number MFCD00037210


Purity ≥98% (TLC)
Apperance white to off-white powder
Solubility H2O: soluble50 mg/mL
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Pictograms GHS09
GHS Signal Word Danger
GHS Hazard statements H301-H331-H373-H410
European Hazard Symbols Toxic Toxic (T)
European Hazard Symbols Nature polluting Nature polluting (N)
GHS Precautionary statements P261-P273-P301 + P310-P311-P501
RID/ADR UN 3283 6.1/PG 2
Risk Statements 23/25-33-50/53
RTECS EK7713840
Safety Statements 20/21-28-45-60-61
Storage Temperature -20°C
Hazard Class 6.1
UN Number 3283
Packing Group 2
German water hazard class 3


Description (English)
Biochem/physiol Actions
Selenomethionine displays antioxidant activity1 and has been shown to increase the activity of glutathione peroxidase in endothelial cells.2 Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite.3,4 Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by selenomethionine in the micromolar range (45 to 130 μM), while growth inhibition of normal fibroblasts required 1 mM selenomethionine.5
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S3132.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.