Oxytetracycline hydrochloride

• Catalog No.: O5875
• CAS Number: 2058-46-0
• M. F.: C22H25ClN2O9
• M. W.: 496.8949
• Purity: ≥95% (HPLC)

SYNONYMS

• Title: 土霉素 盐酸盐
• IUPAC name: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
• IUPAC Traditional name: oxytetracycline hydrochloride

DATABASE IDS

• MDL Number: MFCD00135815
• PubChem SID: 24898027
• Beilstein Number: 3853107
• CAS Number: 2058-46-0
• EC Number: 218-161-2

PROPERTIES

• Purity: ≥95% (HPLC)
• Suitability: suitable for 1694 per US EPA
• Apperance: yellow crystalline
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: QI8225000
• German water hazard class: 2

DETAILS

Description (English)

Application
Oxytetracycline is a tetracycline analog isolated from the actinomycete streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells1 and antibiotic susceptibilities of Mycopasma bovis isolates2. Product O5875 is ≥95% (HPLC), crystalline.
Biochem/physiol Actions
Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.