Spermidine

• Catalog No.: S4139
• CAS Number: 124-20-9
• M. F.: C7H19N3
• M. W.: 145.24586
• Purity: ≥98% (GC)

SYNONYMS

• Title: 亚精胺
• IUPAC name: (4-aminobutyl)(3-aminopropyl)amine
• IUPAC Traditional name: spermidine
• Synonyms: N-(3-氨基丙基)-1,4-丁二胺; 1,8-二氨基-4-氮杂辛烷

DATABASE IDS

• Beilstein Number: 1698591
• PubChem SID: 24899590
• EC Number: 204-689-0
• MDL Number: MFCD00008229
• CAS Number: 124-20-9

PROPERTIES

• Purity: ≥98% (GC)
• Suitability: suitable for cell culture
• Gene Information: rat ... Ppm1a(24666)
• Density: 0.925 g/mL at 25 °C(lit.)
• Flash Point: 112 °C
• Flash Point: 233.6 °F
• Refractive Index: n20/D 1.479(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H314
• European Hazard Symbols: Corrosive (C)
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P280-P305 + P351 + P338-P310
• RID/ADR: UN 2735 8/PG 2
• Risk Statements: 34
• RTECS: EJ7000000
• Safety Statements: 26-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 8
• UN Number: 2735
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (简体中文)

Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.