Streptozocin

• Catalog No.: S0130
• CAS Number: 18883-66-4
• M. F.: C8H15N3O7
• M. W.: 265.2206
• Purity: ≥75% α-anomer basis

SYNONYMS

• IUPAC name: 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
• IUPAC Traditional name: streptozocin
• Synonyms: Streptozotocin; N-(Methylnitrosocarbamoyl)-α-D-glucosamine

DATABASE IDS

• PubChem SID: 24899428
• MDL Number: MFCD00006607
• EC Number: 242-646-8
• Beilstein Number: 2060675
• CAS Number: 18883-66-4

PROPERTIES

• Purity: ≥75% α-anomer basis
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Melting Point: 121 °C (dec.)(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45
• RTECS: LZ5775000
• Safety Statements: 53-45
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Streptozocin is used to induce Type 1 diabetes for medical research.
General description
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
Other Notes
Mixed anomers
包装
1, 5 g in glass bottle
100, 500 mg in glass bottle
50 mg in poly bottle
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.