Adenosine 5′-[γ-thio]triphosphate tetralithium salt

• Catalog No.: A1388
• CAS Number: 93839-89-5
• M. F.: C10H12Li4N5O12P3S
• M. W.: 546.978863
• Purity: ≥75%

SYNONYMS

• IUPAC name: tetralithium(1+) ion [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[dioxido(sulfanylidene)-λ^5-phosphanyl phosphonato]oxy}phosphonate
• IUPAC Traditional name: tetralithium(1+) ion [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [dioxido(sulfanylidene)-λ^5-phosphanyl phosphonato]oxyphosphonate
• Synonyms: Ado-5′-PPP[S]; ATP-γ-S; Adenosine 5′-(3-thiotriphosphate) tetralithium salt

DATABASE IDS

• Beilstein Number: 6265083
• MDL Number: MFCD00077293
• EC Number: 298-862-8
• PubChem SID: 24890536
• CAS Number: 93839-89-5

PROPERTIES

• Purity: ≥75%
• Shipped in: dry ice
• Apperance: white powder
• Solubility: H2O: soluble25 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases.
Other Notes
Non-hydrolyzable ATP analog
Application
Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca2+-activated K+ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.