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Streptomycin sulfate salt_Molecular_structure_CAS_3810-74-0)
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Streptomycin sulfate salt

Catalog No. S1277 Name Sigma Aldrich
CAS Number 3810-74-0 Website http://www.sigmaaldrich.com
M. F. C42H84N14O36S3 Telephone 1-800-521-8956
M. W. 1457.38356 Fax
Purity Email
Storage Chembase ID: 130846

SYNONYMS

Title
链霉素 硫酸盐
IUPAC name
bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
IUPAC Traditional name
bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)

DATABASE IDS

PubChem SID 24899470
CAS Number 3810-74-0
Beilstein Number 3894995
MDL Number MFCD00037023
EC Number 223-286-0

PROPERTIES

Potency ≥720 I.U. per mg
Suitability suitable for mouse embryo cell culture
Apperance powder
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Warning
GHS Hazard statements H302-H361
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P281
Risk Statements 63-22
RTECS WK4990000
Safety Statements 36/37
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Application
Recommended for use in embryo culture at 50 mg/L. Stock solutions should be sterile-filtered and stored at 2-8 °C for up to a month or at -20 °C for extended periods. Solutions are stable at 37 °C for 3 days. Use to inhibit bacterial protein synthesis at the level of initiation. Use to study mechanisms of streptomycin resistance. Use together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.

REFERENCES