Penicillin G potassium salt

• Catalog No.: PENK
• CAS Number: 113-98-4
• M. F.: C16H17KN2O4S
• M. W.: 372.48048

SYNONYMS

• Title: 青霉素 G 钾盐
• IUPAC name: potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• IUPAC Traditional name: potassium benzylpenicillin(1-)
• Synonyms: 苄青霉素 钾盐

DATABASE IDS

• EC Number: 204-038-0
• PubChem SID: 24899067
• CAS Number: 113-98-4
• Beilstein Number: 3832841
• MDL Number: MFCD00036193

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H317
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 42/43
• RTECS: XH9700000
• Safety Statements: 36/37
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Mode of Action: Inhibits bacterial cell wall synthesis.Antimicrobial spectrum: Gram-positive bacteria
Penicillin G is active against gram-positive and gram-negative aerobic and anaerobic bacteria. Penicillin G inhibits cell wall synthesis by binding to penicillin binding proteins (PBPs) which inhibits peptidoglycan chain cross-lining. Penicillin G is stable against hydrolysis by β-lactamases, such as penicillinases and cephalosporinases.
Application
Penicillin G is a narrow spectrum antibiotic. It is the drug of choice for Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Penicillin G potassium salt is used to study murosomes of staphylococci1 and the penicillin-induced lysis of Streptococcus mutans2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information