Neomycin trisulfate salt hydrate

• Catalog No.: N1876
• CAS Number: 1405-10-3
• M. F.: C23H54N6O26S3
• M. W.: 926.89446

SYNONYMS

• Title: 新霉素 三硫酸盐 水合物
• IUPAC name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol tris(sulfuric acid) hydrate
• IUPAC Traditional name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol tris(sulfuric acid) hydrate

DATABASE IDS

• CAS Number: 1405-10-3
• EC Number: 215-773-1
• PubChem SID: 24897532

PROPERTIES

• Apperance: powder
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• Safety Statements: 22-36/37-45
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
作用方式：与引起错编的 30S 和 50S（有时为 50S）亚基结合；抑制蛋白质合成的开始和延长。 抗菌谱：革兰氏阴性和革兰氏阳性细菌。
Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Neomycin blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
Caution
Protect from light and moisture.
Application
Neomycin is used in molecular biology as a selection agent for prokaryotic cells that have been transformed using the selectable marker gene (neo). It is also used to study ototoxic side effects of antibiotics, platelet-derived growth factor (PDGF) responses in C3H/10T1/2 C18 fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins 1,2,3. Product N1876 is supplied as a powder.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information