Spermine

• Catalog No.: S4264
• CAS Number: 71-44-3
• M. F.: C10H26N4
• M. W.: 202.34024
• Purity: ≥96%

SYNONYMS

• Title: 精胺
• IUPAC name: (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
• IUPAC Traditional name: spermine
• Synonyms: 精素; N,N′-双(3-氨基丙基)-1,4-丁二胺; 肌胺; 肝胺

DATABASE IDS

• CAS Number: 71-44-3
• EC Number: 200-754-2
• MDL Number: MFCD00008215
• Beilstein Number: 1750791
• PubChem SID: 24899594

PROPERTIES

• Purity: ≥96%
• Suitability: suitable for cell culture
• Gene Information: human ... GRIN2B(2904)rat ... Grin2a(24409)
• Apperance: amorphous semi-solid
• Boiling Point: 150 °C/5 mmHg(lit.)
• Flash Point: 110 °C
• Flash Point: 230 °F
• Melting Point: 28-30(lit.)
• Solubility: H2O: soluble50 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H314
• European Hazard Symbols: Corrosive (C)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P280-P305 + P351 + P338-P310
• RID/ADR: UN 3259 8/PG 2
• Risk Statements: 34
• RTECS: EJ7175000
• Safety Statements: 26-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 8
• UN Number: 3259
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。