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Catalog No. P4359 Name Sigma Aldrich
CAS Number 63208-82-2 Website http://www.sigmaaldrich.com
M. F. C16H19BrN2OS Telephone 1-800-521-8956
M. W. 367.30386 Fax
Purity ≥95% (HPLC) Email
Storage protect from light Chembase ID: 133304


IUPAC name
2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethan-1-one hydrobromide
IUPAC Traditional name
2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone hydrobromide
2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide


CAS Number 63208-82-2
PubChem SID 24898529
MDL Number MFCD00417851


Purity ≥95% (HPLC)
Shipped in wet ice
Apperance off-white powder
Melting Point 192.1-192.5 °C(lit.)
Solubility DMSO: soluble20 mg/mL
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Condition protect from light
Storage Condition under inert gas
Storage Temperature -20°C
German water hazard class 3


Description (English)
Biochem/physiol Actions
Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.