Pifithrin-α

• Catalog No.: P4359
• CAS Number: 63208-82-2
• M. F.: C16H19BrN2OS
• M. W.: 367.30386
• Purity: ≥95% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethan-1-one hydrobromide
• IUPAC Traditional name: 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone hydrobromide
• Synonyms: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide; PFT-α

DATABASE IDS

• CAS Number: 63208-82-2
• PubChem SID: 24898529
• MDL Number: MFCD00417851

PROPERTIES

• Purity: ≥95% (HPLC)
• Shipped in: wet ice
• Apperance: off-white powder
• Melting Point: 192.1-192.5 °C(lit.)
• Solubility: DMSO: soluble20 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Condition: protect from light
• Storage Condition: under inert gas
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.