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Melittin from honey bee venom_Molecular_structure_CAS_20449-79-0)
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Melittin from honey bee venom

Catalog No. M2272 Name Sigma Aldrich
CAS Number 20449-79-0 Website http://www.sigmaaldrich.com
M. F. C131H229N39O31 Telephone 1-800-521-8956
M. W. 2846.46266 Fax
Purity ≥85% (HPLC) Email
Storage Chembase ID: 106604

SYNONYMS

IUPAC name
(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-6-amino-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S,3S)-2-(2-aminoacetamido)-3-methylpentanamido]acetamido}propanamido]-3-methylbutanamido]-4-methylpentanamido]hexanamido]-3-methylbutanamido]-4-methylpentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]acetamido}-4-methylpentanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-methylpentanamido]-3-methylpentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-3-methylpentanamido]hexanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-carbamoylbutanamido]pentanediamide
IUPAC Traditional name
(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-6-amino-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S,3S)-2-(2-aminoacetamido)-3-methylpentanamido]acetamido}propanamido]-3-methylbutanamido]-4-methylpentanamido]hexanamido]-3-methylbutanamido]-4-methylpentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]acetamido}-4-methylpentanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-methylpentanamido]-3-methylpentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-3-methylpentanamido]hexanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-carbamoylbutanamido]pentanediamide

DATABASE IDS

MDL Number MFCD00076868
CAS Number 20449-79-0
PubChem SID 24896718
EC Number 253-417-7

PROPERTIES

Foreign Activity Phospholipase A2 ≤0.5%
Purity ≥85% (HPLC)
Flash Point 112 °C
Flash Point 233.6 °F
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H312
European Hazard Symbols Harmful Harmful (Xn)
GHS Precautionary statements P280
Risk Statements 21/22
RTECS OS3960000
Safety Statements 36
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Amino Acid Sequence
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Biochem/physiol Actions
Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.
Other Notes
The principle hemolytic component of honeybee venom.

REFERENCES