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Catalog No. G2536 Name Sigma Aldrich
CAS Number 82410-32-0 Website http://www.sigmaaldrich.com
M. F. C9H13N5O4 Telephone 1-800-521-8956
M. W. 255.23062 Fax
Purity ≥99% (HPLC) Email
Storage Chembase ID: 73249


IUPAC name
IUPAC Traditional name


PubChem SID 24278453
CAS Number 82410-32-0
MDL Number MFCD00870588


Purity ≥99% (HPLC)
Quality Level PREMIUM
Absorption Wavelength ε1mM/256 nm 12.0
Apperance white powder
Solubility 0.1 M HCl: soluble10 mg/mL
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H360
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 46-60-61
RTECS MF8407000
Safety Statements 53-36/37/39-45
Storage Temperature 2-8°C
German water hazard class 3


Description (English)
Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.
Biochem/physiol Actions
Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.1 The cell cycle is irreversibly arrested at the G2-M checkpoint.2 Gap junction involvement in the ganciclovir bystander effect has been studied.3 Ganciclovir has been used to study loss of telomeres4 and to evaluate sensitivity of viruses to antiviral treatments.5