Ganciclovir

• Catalog No.: G2536
• CAS Number: 82410-32-0
• M. F.: C9H13N5O4
• M. W.: 255.23062
• Purity: ≥99% (HPLC)

SYNONYMS

• IUPAC name: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one
• IUPAC Traditional name: gancyclovir

DATABASE IDS

• PubChem SID: 24278453
• CAS Number: 82410-32-0
• MDL Number: MFCD00870588

PROPERTIES

• Purity: ≥99% (HPLC)
• Quality Level: PREMIUM
• Absorption Wavelength: ε1mM/256 nm 12.0
• Apperance: white powder
• Solubility: 0.1 M HCl: soluble10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 46-60-61
• RTECS: MF8407000
• Safety Statements: 53-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.
Biochem/physiol Actions
Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.1 The cell cycle is irreversibly arrested at the G2-M checkpoint.2 Gap junction involvement in the ganciclovir bystander effect has been studied.3 Ganciclovir has been used to study loss of telomeres4 and to evaluate sensitivity of viruses to antiviral treatments.5