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Rottlerin

Catalog No. R5648 Name Sigma Aldrich
CAS Number 82-08-6 Website http://www.sigmaaldrich.com
M. F. C30H28O8 Telephone 1-800-521-8956
M. W. 516.53852 Fax
Purity ≥85% Email
Storage Chembase ID: 109393

SYNONYMS

IUPAC name
(2E)-1-{6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl}-3-phenylprop-2-en-1-one
IUPAC Traditional name
rottlerin
Synonyms
1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
Mallotoxin

DATABASE IDS

CAS Number 82-08-6
PubChem SID 24278679
MDL Number MFCD00017361
EC Number 201-395-4

PROPERTIES

Purity ≥85%
Gene Information human ... CDK2(1017)
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS AM6913800
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Recently, Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. Mallatoxin tested on hERG channels increased both step and tail hERG current by leftward shifting the voltage dependence of hERG activation and slowing channel deactivation. These actions distinguish Mallatoxin as a novel naturally occurring hERG channel activator.

REFERENCES