Rottlerin

• Catalog No.: R5648
• CAS Number: 82-08-6
• M. F.: C30H28O8
• M. W.: 516.53852
• Purity: ≥85%

SYNONYMS

• IUPAC name: (2E)-1-{6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl}-3-phenylprop-2-en-1-one
• IUPAC Traditional name: rottlerin
• Synonyms: 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; Mallotoxin

DATABASE IDS

• CAS Number: 82-08-6
• PubChem SID: 24278679
• MDL Number: MFCD00017361
• EC Number: 201-395-4

PROPERTIES

• Purity: ≥85%
• Gene Information: human ... CDK2(1017)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: AM6913800
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Recently, Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. Mallatoxin tested on hERG channels increased both step and tail hERG current by leftward shifting the voltage dependence of hERG activation and slowing channel deactivation. These actions distinguish Mallatoxin as a novel naturally occurring hERG channel activator.