(+)-MK-801 hydrogen maleate

• Catalog No.: M107
• CAS Number: 77086-22-7
• M. F.: C20H19NO4
• M. W.: 337.36916

SYNONYMS

• IUPAC name: (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^2,^7.0^1^0,^1^5]hexadeca-2,4,6,10(15),11,13-hexaene; (2Z)-but-2-enedioic acid
• IUPAC Traditional name: (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^2,^7.0^1^0,^1^5]hexadeca-2,4,6,10(15),11,13-hexaene; maleic acid
• Synonyms: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate; Dizocilpine hydrogen maleate

DATABASE IDS

• MDL Number: MFCD00082465
• EC Number: 278-614-5
• PubChem SID: 24277988
• CAS Number: 77086-22-7

PROPERTIES

• Gene Information: human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)
• Apperance: white powder
• Optical Rotation: [α]25/D +117°, c = 1 in methanol(lit.)
• Solubility: DMSO: >20 mg/mL
• Solubility: H2O: soluble6 mg/mL
• Solubility: 0.1 M HCl: soluble
• Solubility: ethanol: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: HP1093575
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Highly potent and selective non-competitive NMDA glutamate receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Inhibits behavioral sensitization to psychostimulants and ethanol.