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(+)-MK-801 hydrogen maleate_Molecular_structure_CAS_77086-22-7)
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(+)-MK-801 hydrogen maleate

Catalog No. M107 Name Sigma Aldrich
CAS Number 77086-22-7 Website http://www.sigmaaldrich.com
M. F. C20H19NO4 Telephone 1-800-521-8956
M. W. 337.36916 Fax
Purity Email
Storage Chembase ID: 133281


IUPAC name
(1S,9R)-1-methyl-16-azatetracyclo[,7.010,15]hexadeca-2,4,6,10(15),11,13-hexaene; (2Z)-but-2-enedioic acid
IUPAC Traditional name
(1S,9R)-1-methyl-16-azatetracyclo[,7.010,15]hexadeca-2,4,6,10(15),11,13-hexaene; maleic acid
(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
Dizocilpine hydrogen maleate


MDL Number MFCD00082465
EC Number 278-614-5
PubChem SID 24277988
CAS Number 77086-22-7


Gene Information human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)
Apperance white powder
Optical Rotation [α]25/D +117°, c = 1 in methanol(lit.)
Solubility DMSO: >20 mg/mL
Solubility H2O: soluble6 mg/mL
Solubility 0.1 M HCl: soluble
Solubility ethanol: soluble
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS HP1093575
German water hazard class 3


Description (English)
Biochem/physiol Actions
Highly potent and selective non-competitive NMDA glutamate receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Inhibits behavioral sensitization to psychostimulants and ethanol.