Polymyxin B nonapeptide hydrochloride

• Catalog No.: P2076
• M. F.: C43H74N14O11
• M. W.: 963.13486

SYNONYMS

• IUPAC name: 2-amino-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)-3-hydroxybutanamide
• IUPAC Traditional name: 2-amino-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)-3-hydroxybutanamide
• Synonyms: PMBN

DATABASE IDS

• MDL Number: MFCD00214217
• PubChem SID: 24898270

PROPERTIES

• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.1,2,3 PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.4
Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.