Home > Compound List > Product Information
Amitriptyline hydrochloride_Molecular_structure_CAS_549-18-8)
Click picture or here to close

Amitriptyline hydrochloride

Catalog No. A8404 Name Sigma Aldrich
CAS Number 549-18-8 Website http://www.sigmaaldrich.com
M. F. C20H24ClN Telephone 1-800-521-8956
M. W. 313.86426 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 105418


阿米替林 盐酸盐
IUPAC name
dimethyl({3-[(2Z)-tricyclo[,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene]propyl})amine hydrochloride
IUPAC Traditional name
dimethyl({3-[(2Z)-tricyclo[,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene]propyl})amine hydrochloride


EC Number 208-964-6
MDL Number MFCD00012537
PubChem SID 24278073
CAS Number 549-18-8


Purity ≥98% (TLC)
Gene Information human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Apperance white to off-white powder
Solubility H2O: soluble
Solubility ethanol: soluble
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H301-H361
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P281-P301 + P310
RID/ADR UN 2811 6.1/PG 3
Risk Statements 63-22
RTECS HO9450000
Safety Statements 22
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 2811
Packing Group 3
German water hazard class 3


Description (简体中文)
Features and Benefits
Shelf-life of the powder is at least three years.
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
Biochem/physiol Actions
三环抗抑郁剂;抑制分别具有 100nM 和 14.7nM Kis 的去甲肾上腺素和 5-羟色胺转运蛋白;对 α1-肾上腺素受体、5-羟色胺和毒蕈碱型乙酰胆碱受体具有高度的体外亲和力。