N-Acetyl-Asp-Glu

• Catalog No.: A5930
• CAS Number: 3106-85-2
• M. F.: C11H16N2O8
• M. W.: 304.25334
• Purity: ≥97% (TLC)

SYNONYMS

• IUPAC name: 2-(3-carboxy-2-acetamidopropanamido)pentanedioic acid
• IUPAC Traditional name: 2-(3-carboxy-2-acetamidopropanamido)pentanedioic acid
• Synonyms: Spaglumic acid; NAAG

DATABASE IDS

• PubChem SID: 24891036
• CAS Number: 3106-85-2
• MDL Number: MFCD00076652

PROPERTIES

• Purity: ≥97% (TLC)
• Gene Information: human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907), GRM3(2913)mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168), GRM3(108069)rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668), GRM3(24416)
• Apperance: white powder
• Optical Rotation: [α]22/D -34.5°, c = 1.1 in H2O(lit.)
• Solubility: H2O: soluble50 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
NAc-Asp-Glu
Caution
Store desiccated.
Biochem/physiol Actions
Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A5930.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.