Kainic acid monohydrate

• Catalog No.: K0250
• CAS Number: 58002-62-3
• M. F.: C10H17NO5
• M. W.: 231.24568
• Purity: ≥99% (TLC)

SYNONYMS

• IUPAC name: (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid hydrate
• IUPAC Traditional name: kainic acid hydrate
• Synonyms: 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

DATABASE IDS

• CAS Number: 58002-62-3
• PubChem SID: 24277985
• MDL Number: MFCD00150833

PROPERTIES

• Impurities: Glutamate, free
• Purity: ≥99% (TLC)
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901), SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)mouse ... Gria1(14799)rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
• Solubility: H2O: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy.
General description
Kainic acid is an agonist for kainate-class ionotropic glutamate receptors. Kainate receptors directly gate ion channels and are generally excitatory. Excess stimulation by Kainic acid induces neurocytosis (apoptosis) and epileptic seizures.
Preparation Note
Dissolve in 1-2 drops of 1N NaOH then bring to volume with water or aqueous buffer. Can be stored 1-2 days refrigerated.
Biochem/physiol Actions
Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.