Triacsin C from Streptomyces sp.

• Catalog No.: T4540
• CAS Number: 76896-80-5
• M. F.: C11H17N3O
• M. W.: 207.27218

SYNONYMS

• IUPAC name: (E)-1-nitroso-2-[(2E,4E,7E)-undeca-2,4,7-trien-1-ylidene]hydrazine
• IUPAC Traditional name: triacsin C
• Synonyms: 2,4,7-Undecatrienal nitrosohydrazone; WS1228A

DATABASE IDS

• MDL Number: MFCD00798237
• CAS Number: 76896-80-5
• PubChem SID: 24900214

PROPERTIES

• Shipped in: wet ice
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
General description
Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus.