Trifluorothymidine

• Catalog No.: T2255
• CAS Number: 70-00-8
• M. F.: C10H11F3N2O5
• M. W.: 296.1999496
• Purity: ≥99% (HPLC)

SYNONYMS

• IUPAC name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: trifluridine
• Synonyms: 2′-Deoxy-5-trifluoromethyluridine; Trifluridine; α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside

DATABASE IDS

• EC Number: 200-722-8
• MDL Number: MFCD00006534
• PubChem SID: 24900027
• CAS Number: 70-00-8

PROPERTIES

• Purity: ≥99% (HPLC)
• Melting Point: 190-193 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332-H351
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22-40
• RTECS: XP2087500
• Safety Statements: 22-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).