Erythromycin stearate

• Catalog No.: E9256
• CAS Number: 643-22-1
• M. F.: C55H103NO15
• M. W.: 1018.40402

SYNONYMS

• IUPAC name: (3S,4R,5R,6S,7S,9S,12R,14S)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione; octadecanoic acid
• IUPAC Traditional name: (3S,4R,5R,6S,7S,9S,12R,14S)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione; stearic acid

DATABASE IDS

• MDL Number: MFCD00084690
• EC Number: 211-396-1
• PubChem SID: 24894693
• CAS Number: 643-22-1

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• RTECS: KF5785000
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Erythromycin stearate is used to study leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes1. It is also used to study abnormal polymorphonuclear leucocyte migration and chemotaxis2,3.
Biochem/physiol Actions
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).