Sulconazole nitrate salt

• Catalog No.: S9632
• CAS Number: 61318-91-0
• M. F.: C18H16Cl3N3O3S
• M. W.: 460.76194

SYNONYMS

• IUPAC name: 1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; nitric acid
• IUPAC Traditional name: acid, nitric; sulconazole
• Synonyms: 1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

DATABASE IDS

• PubChem SID: 24899846
• MDL Number: MFCD00058163
• CAS Number: 61318-91-0

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: NI4475000
• Safety Statements: 36
• German water hazard class: 3

DETAILS

Description (English)

Application
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus1. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases2.
Biochem/physiol Actions
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro2.