Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

• Catalog No.: T7254
• CAS Number: 4272-74-6
• M. F.: C14H22Cl2N2O3S
• M. W.: 369.30708
• Purity: ≥96% (TLC)

SYNONYMS

• IUPAC name: (3S)-7-amino-1-chloro-S-(4-methylphenyl)-2-oxoheptane-3-sulfonamido hydrochloride
• IUPAC Traditional name: C14H21ClN2O3S hydrochloride
• Synonyms: (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride; (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride; TLCK; Tosyl-L-lysyl-chloromethane hydrochloride

DATABASE IDS

• PubChem SID: 24278752
• MDL Number: MFCD00065395
• CAS Number: 4272-74-6
• EC Number: 224-266-4
• Beilstein Number: 7106867

PROPERTIES

• Potency: 10-100 μM effective concentration
• Purity: ≥96% (TLC)
• Gene Information: human ... NFKB1(4790), NFKB2(4791)
• Apperance: powder
• Solubility: H2O: soluble50 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NF-κB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis in cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli.
Caution
Stable at least two years when stored desiccated at -20°C.