Leupeptin trifluoroacetate salt

• Catalog No.: L2023
• CAS Number: 147385-61-3
• M. F.: C22H39F3N6O6
• M. W.: 540.5768696
• Purity: ≥90% (HPLC)

SYNONYMS

• Title: 亮抑酶肽 三氟乙酸盐
• IUPAC name: (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl}-3-methylbutyl]-2-acetamido-4-methylpentanamide; trifluoroacetic acid
• IUPAC Traditional name: (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl}-3-methylbutyl]-2-acetamido-4-methylpentanamide; trifluoroacetic acid
• Synonyms: Acetyl-Leu-Leu-Arg-al 三氟乙酸盐

DATABASE IDS

• CAS Number: 147385-61-3
• MDL Number: MFCD00133458

PROPERTIES

• Biological Source: microbial
• Purity: ≥90% (HPLC)
• Solubility: H2O: soluble10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at -20 °C.)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Analysis Note
由于三种形式在溶液中达到平衡，亮抑酶肽可在 HPLC 上形成多个峰。通过三个主峰测定纯度。主要的杂质肽为外消旋亮抑酶肽。
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin.1 (Loss of cochlear hair cells is believed to be mediated by calpain.)