5-(N,N-Dimethyl)amiloride hydrochloride

• Catalog No.: A4562
• CAS Number: 1214-79-5
• M. F.: C8H13Cl2N7O
• M. W.: 294.14112

SYNONYMS

• Title: 5-(N,N-二甲基)阿米洛利 盐酸盐
• IUPAC name: 3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide hydrochloride
• IUPAC Traditional name: 3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide hydrochloride
• Synonyms: 3-氨基-N-(氨基亚氨基乙基)-5-(二甲氨基)-6-氯吡嗪甲酰胺 盐酸盐; DMA

DATABASE IDS

• MDL Number: MFCD00069207
• CAS Number: 1214-79-5
• PubChem SID: 24278216

PROPERTIES

• Gene Information: human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Selective blocker of Na+/H+ antiport; IC50 = 6.9 μM.
Application
5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na2/H+ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.