5-Iodotubericidin

• Catalog No.: I100
• CAS Number: 24386-93-4
• M. F.: C11H13IN4O4
• M. W.: 392.14979
• Purity: ≥90%

SYNONYMS

• IUPAC name: (2R,3R,4S,5R)-2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol
• IUPAC Traditional name: 5-iodotubercidin
• Synonyms: 5-Iodotubericidin; 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 7-Iodo-7-deazaadenosine

DATABASE IDS

• MDL Number: MFCD00055131
• CAS Number: 24386-93-4

PROPERTIES

• Purity: ≥90%
• Apperance: tan solid
• Solubility: 0.1 M HCl: soluble0.7 mg/mL
• Solubility: 0.1 M NaOH: soluble0.8 mg/mL
• Solubility: DMSO: soluble36 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
5-Iodotubercidin increases fatty acid oxidation activity and glycogen synthesis in hepatocytes. 5-Iodotubercidin is also a potent inhibitor of adenosine uptake into brain.
Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.1
Caution
Solutions may be stored frozen. Use promptly when thawed and protect from exposure to light.