S(+)-Niguldipine hydrochloride

• Catalog No.: N135
• CAS Number: 113165-32-5
• M. F.: C36H40ClN3O6
• M. W.: 646.1723

SYNONYMS

• IUPAC name: 3-[3-(4,4-diphenylpiperidin-1-yl)propyl] 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
• IUPAC Traditional name: 3-[3-(4,4-diphenylpiperidin-1-yl)propyl] 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
• Synonyms: S(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride

DATABASE IDS

• CAS Number: 113165-32-5
• MDL Number: MFCD00873564
• PubChem SID: 24897482

PROPERTIES

• Apperance: yellow solid
• Optical Rotation: [α]22/D +14.62°, c = 0.13 in methanol(lit.)
• Solubility: DMSO: soluble13 mg/mL
• Solubility: ethanol: soluble16 mg/mL
• Solubility: methanol: soluble8 mg/mL
• Solubility: H2O: insoluble
• Solubility: dilute aqueous acid: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Caution
Photosensitive. This compound adsorbs strongly to plastic.
Biochem/physiol Actions
α1A-adrenoceptor antagonist; antihypertensive agent; L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channels.