Indomethacin

• Catalog No.: I7378
• CAS Number: 53-86-1
• M. F.: C19H16ClNO4
• M. W.: 357.78764
• Purity: ≥99% (TLC)

SYNONYMS

• Title: 吲哚美辛
• IUPAC name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• IUPAC Traditional name: indomethacin
• Synonyms: 1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚乙酸

DATABASE IDS

• MDL Number: MFCD00057095
• EC Number: 200-186-5
• PubChem SID: 24278173
• CAS Number: 53-86-1
• Beilstein Number: 497341

PROPERTIES

• Purity: ≥99% (TLC)
• Gene Information: human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224)rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P301 + P310
• RID/ADR: UN 2811 6.1/PG 1
• Risk Statements: 28
• RTECS: NL3500000
• Safety Statements: 28-36/37-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。