Phorbol 12,13-didecanoate

• Catalog No.: P9018
• CAS Number: 24928-17-4
• M. F.: C40H64O8
• M. W.: 672.93136

SYNONYMS

• IUPAC name: (1S,2S,6R,10S,11R,13S,14R,15R)-14-(decanoyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0^2,^6.0^1^1,^1^3]pentadeca-3,8-dien-13-yl decanoate
• IUPAC Traditional name: (1S,2S,6R,10S,11R,13S,14R,15R)-14-(decanoyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0^2,^6.0^1^1,^1^3]pentadeca-3,8-dien-13-yl decanoate
• Synonyms: PDD; Phorbol 12,13-dicaprinate

DATABASE IDS

• Beilstein Number: 6036113
• MDL Number: MFCD00065449
• PubChem SID: 24899003
• CAS Number: 24928-17-4

PROPERTIES

• Apperance: white solid
• Solubility: DMSO: soluble
• Solubility: ethanol: soluble
• Solubility: methanol: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: GZ0653000
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.
Caution
Photosensitive
General description
More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent
Reconstitution
A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.