Palmitoyl-L-carnitine chloride

• Catalog No.: P1645
• CAS Number: 18877-64-0
• M. F.: C23H46ClNO4
• M. W.: 436.06864
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: [(2R)-3-carboxy-2-(hexadecanoyloxy)propyl]trimethylazanium chloride
• IUPAC Traditional name: [(2R)-3-carboxy-2-(hexadecanoyloxy)propyl]trimethylazanium chloride
• Synonyms: O-Palmitoyl-L-carnitine chloride

DATABASE IDS

• CAS Number: 18877-64-0
• Beilstein Number: 4071005
• EC Number: 242-642-6
• PubChem SID: 24898229
• MDL Number: MFCD00070346

PROPERTIES

• Purity: ≥98% (TLC)
• Apperance: white powder
• Solubility: H2O: soluble25 mg/mL (with heat or sonication)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.