Hygromycin B from Streptomyces hygroscopicus

• Catalog No.: H7772
• CAS Number: 31282-04-9
• M. F.: C20H37N3O13
• M. W.: 527.52008

SYNONYMS

• Title: 潮霉素 B 来源于吸水链霉菌
• IUPAC name: (2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
• IUPAC Traditional name: (2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol

DATABASE IDS

• MDL Number: MFCD06795479
• PubChem SID: 24895807
• CAS Number: 31282-04-9
• EC Number: 250-545-5

PROPERTIES

• Purified By: ion-exchange chromatography
• Apperance: lyophilized powder
• GHS Signal Word: Danger
• GHS Hazard statements: H300 +H310 + H330-H318-H334
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 26/27/28-41-42/43
• RTECS: WK2130000
• Safety Statements: 22-26-28-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Mode of Action: Blocks polypeptide synthesis and inhibits elongation. For use in the selection and maintenance of prokaryotic and eukaryotic cells.
Application
Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. It is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. It is used in gene transfer experiments as a selection agent1,2,3.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information