Ouabain octahydrate

• Catalog No.: O3125
• CAS Number: 11018-89-6
• M. F.: C29H60O20
• M. W.: 728.7747
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 4-[(1S,2R,3R,5S,7S,10R,11S,14R,15R,17R)-3,7,11,17-tetrahydroxy-2-(hydroxymethyl)-15-methyl-5-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]-2,5-dihydrofuran-2-one octahydrate
• IUPAC Traditional name: ouabain octahydrate
• Synonyms: 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside); G-Strophanthin; Acocantherine

DATABASE IDS

• EC Number: 211-139-3
• PubChem SID: 24278610
• MDL Number: MFCD00149240
• CAS Number: 11018-89-6
• Beilstein Number: 101712

PROPERTIES

• Impurities: ~8 mol/mol water
• Purity: ≥95% (HPLC)
• Gene Information: human ... ATIC(471)rat ... Atp1b1(25650)
• Absorption Wavelength: ε1mM/220 nm, H2O 15.5
• Apperance: white powder
• Optical Rotation: [α]25/D -31 to -32.5° in H2O(lit.)
• Solubility: H2O: soluble10 mg/mL (cold)
• Solubility: ethanol: soluble10 mg/mL
• Solubility: H2O: soluble50 mg/mL (hot)
• GHS Signal Word: Danger
• GHS Hazard statements: H301 + H331-H373
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P261-P301 + P310-P311
• RID/ADR: UN 1544 6.1/PG 1
• Risk Statements: 23/25-33
• Safety Statements: 45
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Caution
Aqueous solutions can be autoclaved.
Biochem/physiol Actions
Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity.