Streptonigrin from Streptomyces flocculus

• Catalog No.: S1014
• CAS Number: 3930-19-6
• M. F.: C25H22N4O8
• M. W.: 506.46418
• Purity: ≥98%

SYNONYMS

• IUPAC name: 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
• IUPAC Traditional name: nigrin
• Synonyms: Bruneomycin; Nigrin

DATABASE IDS

• CAS Number: 3930-19-6
• PubChem SID: 24899458
• MDL Number: MFCD00063401
• Beilstein Number: 599390
• EC Number: 223-501-8

PROPERTIES

• Purity: ≥98%
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P301 + P310
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 28
• RTECS: TJ7350000
• Safety Statements: 53-28-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.