Arachidonic acid

• Catalog No.: A9673
• CAS Number: 506-32-1
• M. F.: C20H32O2
• M. W.: 304.46688
• Purity: ≥99% (GC)

SYNONYMS

• Title: 花生四烯酸
• IUPAC name: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
• IUPAC Traditional name: arachidonic acid
• Synonyms: Immunocytophyte; 全顺式-5,8,11,14-二十碳四烯酸; 二十碳-5Z,8Z,11Z,14Z-四烯酸

DATABASE IDS

• EC Number: 208-033-4
• PubChem SID: 24891487
• CAS Number: 506-32-1
• Beilstein Number: 1713889
• MDL Number: MFCD00004417

PROPERTIES

• Biological Source: from porcine liver
• Purity: ≥99% (GC)
• Shipped in: dry ice
• Apperance: clear colorless to very faintly yellow liquid
• Boiling Point: 169-171 °C/0.15 mmHg(lit.)
• Density: 0.922 g/mL at 25 °C(lit.)
• Flash Point: 113 °C
• Flash Point: 235.4 °F
• Melting Point: -49 °C(lit.)
• Refractive Index: n20/D 1.4872(lit.)
• Solubility: ethanol: ≥10 mg/mL (lit.)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• Risk Statements: 19
• RTECS: CE6675000
• Storage Temperature: -20°C
• Supplemental Hazard Statements: May form explosive peroxides.
• German water hazard class: 3

DETAILS

Description (简体中文)

包装
1 g in ampule
10, 50, 100, 500 mg in ampule
Sealed ampule
Biochem/physiol Actions
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
花生四烯酸 (AA) 是一种 ω6 不饱和脂肪酸，是细胞膜磷脂的组分。在炎症反应中，水解磷脂酶 A2 可将 AA 从膜磷脂中释放出来。然后，AA 可被至少两种环加氧酶 (COX) 亚型代谢为前列腺素和血栓烷，被脂氧合酶代谢为白三烯和脂氧素，以及通过细胞色素 p450 催化代谢为环氧-二十碳三烯酸。AA 及其代谢产物在多种生物过程中发挥着重要作用，包括信号转导、平滑肌收缩、趋化性、细胞增殖和分化，以及细胞凋亡。已证实 AA 可与 G 蛋白的亚基结合，抑制 Ras GTP 酶激活蛋白 (GAP) 的活性。AA 的细胞摄取需要消耗能量并涉及跨细胞质膜的蛋白质辅助运输。