5-Azacytidine

• Catalog No.: A2385
• CAS Number: 320-67-2
• M. F.: C8H12N4O5
• M. W.: 244.20468
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: 5-氮杂胞嘧啶核苷
• IUPAC name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
• IUPAC Traditional name: azacitidine
• Synonyms: 5-Azacitidine; 阿扎胞苷; 4-氨基-1-(β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)-酮

DATABASE IDS

• Beilstein Number: 620461
• MDL Number: MFCD00006539
• PubChem SID: 24278211
• CAS Number: 320-67-2
• EC Number: 206-280-2

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: human ... DNMT1(1786), DNMT3A(1788), DNMT3B(1789)
• Melting Point: 226-232 °C (dec.)(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45-46-22
• RTECS: XZ3017500
• Safety Statements: 22-36/37/39-45
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
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包装
1 g in poly bottle
100, 250 mg in poly bottle
Biochem/physiol Actions
Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes.
一种强效生长抑制剂及细胞毒素剂，抑制 DNA 甲基转移酶，一种基因表达、基因激活和沉默的重要调节机制。