D-Penicillamine

• Catalog No.: P4875
• CAS Number: 52-67-5
• M. F.: C5H11NO2S
• M. W.: 149.21134
• Purity: 98-101%

SYNONYMS

• Title: D-青霉胺
• IUPAC name: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
• IUPAC Traditional name: depen
• Synonyms: 3,3-二甲基-D-半胱氨酸; D-(-)-2-氨基-3-巯基-3-甲基丁酸; 3-巯基-D-缬氨酸

DATABASE IDS

• MDL Number: MFCD00064302
• EC Number: 200-148-8
• CAS Number: 52-67-5
• PubChem SID: 24898564
• Beilstein Number: 1722375

PROPERTIES

• Purity: 98-101%
• Gene Information: mouse ... Oprk1(18387)
• Melting Point: 210 °C (dec.)(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: YV9425000
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (简体中文)

包装
5, 25 g in poly bottle
Application
It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding1 and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes2.
Biochem/physiol Actions
Penicillamine is a haracteristic degradation product of penicillin type antibiotics. One atom of copper combines with two molecules of penicillamine. Penicillamine reduces excess cystine excretion in cystinuria. This is by disulfide interchange between penicillamine and cystine, which results in formation of a readily excreted penicillamine-cysteine disulfide. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. Penicillamine lowers IgM rheumatoid factor and depresses T-cell activity.