Pyrrolnitrin from Pseudomonas cepacia

• Catalog No.: P8861
• M. F.: C10H6Cl2N2O2
• M. W.: 257.07284
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-chloro-4-(3-chloro-2-nitrophenyl)-1H-pyrrole
• IUPAC Traditional name: pyrrolnitrin
• Synonyms: 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole

DATABASE IDS

• PubChem SID: 24898985
• EC Number: 213-812-7
• MDL Number: MFCD00865605

PROPERTIES

• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: solid
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: UX9450000
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Specificity
The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.
Biochem/physiol Actions
Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.