Etoposide

• Catalog No.: E1383
• CAS Number: 33419-42-0
• M. F.: C29H32O13
• M. W.: 588.55658
• Purity: ≥98%

SYNONYMS

• IUPAC name: (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^3,^7.0^1^1,^1^5]hexadeca-1,3(7),8-trien-12-one
• IUPAC Traditional name: etoposide
• Synonyms: VP-16-213; 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)

DATABASE IDS

• MDL Number: MFCD00869325
• EC Number: 251-509-1
• PubChem SID: 24278178
• CAS Number: 33419-42-0

PROPERTIES

• Biological Source: synthetic
• Purity: ≥98%
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), TOP2A(7153)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Top2a(360243)
• pKa: 9.8
• Apperance: white powder
• Melting Point: 236-251 °C(lit.)
• Solubility: DMSO: soluble30 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45-22
• RTECS: KC0190000
• Safety Statements: 53-45
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.